Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.65 |
| ▸ | JAK2 | O60674 | 6/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12425915 | 0.82 | JAK1 (0.47) | JAK1KMT2AL3MBTL1 | |
| SCHEMBL12425899 | 0.79 | JAK1 (0.46) | JAK1JAK2TYK2JAK3DRD2 | |
| SCHEMBL12385111 | 0.79 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL12385110 | 0.79 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL22511963 | 0.79 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL12385125 | 0.79 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2277170 | 0.79 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL12425794 | 0.77 | JAK1 (0.42) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL31376648 | 0.74 | JAK1 (0.62) | JAK1JAK2TYK2JAK3RET | |
| SCHEMBL12424736 | 0.74 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022068933-A1 | COMPOUNDS AND METHODS OF TREATING DISEASES | CULLGEN (SHANGHAI) , INC. (CN) | 2022-04-07 | — | — | WO | disclosed |