Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327043 | 0.88 | EGFR (0.61) | EGFRPTK2TTKALKJAK2 | |
| SCHEMBL24327080 | 0.86 | PTK2 (0.48) | EGFRPTK2ALKMAP4K1JAK2 | |
| SCHEMBL24351186 | 0.86 | EGFR (0.66) | EGFRPTK2TTKALKMAP4K1 | |
| SCHEMBL24327433 | 0.83 | ALK (0.49) | EGFRPTK2ALKMAP4K1INSR | |
| SCHEMBL24327565 | 0.81 | EGFR (0.61) | EGFRPTK2ALKMAP4K1JAK2 | |
| SCHEMBL24327561 | 0.80 | EGFR (0.72) | EGFRPTK2TTKALKMAP4K1 | |
| SCHEMBL24327417 | 0.79 | EGFR (0.59) | EGFRPTK2ALKMAP4K1KDR | |
| SCHEMBL24327505 | 0.77 | ALK (0.57) | EGFRALKMAP4K1INSRIGF1R | |
| SCHEMBL24327087 | 0.77 | EGFR (0.58) | EGFRPTK2ALKJAK2KDR | |
| SCHEMBL24327674 | 0.77 | PTK2 (0.57) | EGFRPTK2TTKALKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |