Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.42 |
| ▸ | CCNK | O75909 | 2/20 | 0.42 |
| ▸ | CCND3 | P30281 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 5/20 | 0.41 |
| ▸ | INSR | P06213 | 3/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327431 | 0.87 | ALK (0.53) | ALKPTK2EGFRCDK6CCNK | |
| SCHEMBL24327080 | 0.86 | PTK2 (0.48) | ALKPTK2EGFRIGF1RINSR | |
| SCHEMBL24327044 | 0.83 | EGFR (0.55) | ALKPTK2EGFRIGF1RINSR | |
| SCHEMBL29015721 | 0.80 | ALK (0.53) | ALKPTK2EGFRCDK6CCNK | |
| SCHEMBL24327576 | 0.80 | PTK2 (0.51) | ALKPTK2EGFRCDK6CCNK | |
| SCHEMBL24327429 | 0.78 | ALK (0.47) | ALKPTK2EGFRIGF1R | |
| SCHEMBL24328493 | 0.78 | ALK (0.47) | ALKPTK2EGFRIGF1RMAP4K1 | |
| SCHEMBL24327674 | 0.77 | PTK2 (0.57) | ALKPTK2EGFRIGF1RINSR | |
| SCHEMBL24327386 | 0.76 | ALK (0.46) | ALKPTK2IGF1RMAP4K1 | |
| SCHEMBL24351186 | 0.76 | EGFR (0.66) | ALKPTK2EGFRIGF1RINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |