Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.39 |
| ▸ | TYK2 | P29597 | 13/20 | 0.39 |
| ▸ | JAK1 | P23458 | 12/20 | 0.39 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327333 | 0.88 | JAK2 (0.44) | JAK2TYK2JAK1JAK3CNR1 | |
| SCHEMBL29601453 | 0.88 | JAK2 (0.44) | JAK2TYK2JAK1JAK3CNR1 | |
| SCHEMBL24327328 | 0.88 | JAK2 (0.44) | JAK2TYK2JAK1JAK3CNR1 | |
| SCHEMBL24327357 | 0.86 | JAK2 (0.39) | JAK2TYK2JAK1JAK3CNR1 | |
| SCHEMBL29601470 | 0.85 | JAK2 (0.40) | JAK2TYK2JAK1JAK3CNR1 | |
| SCHEMBL24328761 | 0.83 | JAK2 (0.38) | JAK2TYK2JAK1JAK3CNR1 | |
| SCHEMBL24327836 | 0.83 | CNR1 (0.39) | JAK2TYK2JAK1JAK3CNR1 | |
| SCHEMBL24327772 | 0.82 | JAK2 (0.38) | JAK2TYK2JAK1JAK3CNR1 | |
| SCHEMBL24327876 | 0.82 | CNR1 (0.38) | JAK2TYK2JAK1JAK3CNR1 | |
| SCHEMBL24327974 | 0.81 | JAK2 (0.41) | JAK2TYK2JAK1JAK3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369097-B | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |