Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | TYK2 | P29597 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327878 | 0.88 | EPHB4 (0.42) | JAK2JAK1TYK2JAK3TTK | |
| SCHEMBL24327876 | 0.88 | CNR1 (0.38) | AHRCHEK1JAK2JAK1TYK2 | |
| SCHEMBL24327880 | 0.85 | CNR1 (0.40) | CHEK1JAK2TYK2MAPKAPK2CLK1 | |
| SCHEMBL24327400 | 0.85 | AHR (0.41) | AHRCHEK1JAK2JAK1TYK2 | |
| SCHEMBL24327395 | 0.85 | JAK2 (0.44) | AHRCHEK1JAK2JAK1TYK2 | |
| SCHEMBL24327768 | 0.82 | AHR (0.42) | AHRJAK2JAK1TYK2JAK3 | |
| SCHEMBL24327328 | 0.81 | JAK2 (0.44) | AHRJAK2JAK1TYK2JAK3 | |
| SCHEMBL29601453 | 0.81 | JAK2 (0.44) | AHRJAK2JAK1TYK2JAK3 | |
| SCHEMBL24327333 | 0.81 | JAK2 (0.44) | AHRJAK2JAK1TYK2JAK3 | |
| SCHEMBL24328754 | 0.80 | JAK2 (0.39) | AHRCHEK1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369097-B | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |