Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.57 |
| ▸ | TTK | P33981 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.51 |
| ▸ | INSR | P06213 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328341 | 0.93 | EGFR (0.67) | EGFRALKINSRIGF1RZAP70 | |
| SCHEMBL24327480 | 0.93 | EGFR (0.57) | EGFRALKINSRIGF1RZAP70 | |
| SCHEMBL24327466 | 0.89 | EGFR (0.65) | EGFRALKINSRIGF1RZAP70 | |
| SCHEMBL24327472 | 0.87 | EGFR (0.64) | EGFRALKINSRIGF1RZAP70 | |
| SCHEMBL24328571 | 0.87 | EGFR (0.50) | EGFRTTKALKINSRIGF1R | |
| SCHEMBL24327366 | 0.87 | EGFR (0.55) | EGFRALKINSRIGF1RZAP70 | |
| SCHEMBL26778373 | 0.86 | ALK (0.69) | EGFRTTKALKINSRIGF1R | |
| SCHEMBL24328348 | 0.86 | EGFR (0.65) | EGFRALKINSRIGF1RZAP70 | |
| SCHEMBL24327355 | 0.86 | EGFR (0.62) | EGFRALKINSRIGF1RZAP70 | |
| SCHEMBL24327331 | 0.86 | EGFR (0.62) | EGFRTTKALKINSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |