Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.57 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.57 |
| ▸ | INSR | P06213 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24328341 | 0.96 | EGFR (0.67) | EGFRALKZAP70INSRIGF1R | |
| SCHEMBL24327472 | 0.90 | EGFR (0.64) | EGFRALKZAP70INSRIGF1R | |
| SCHEMBL24327452 | 0.89 | EGFR (0.57) | EGFRALKZAP70INSRIGF1R | |
| SCHEMBL24327355 | 0.89 | EGFR (0.62) | EGFRALKZAP70INSRIGF1R | |
| SCHEMBL24328348 | 0.89 | EGFR (0.65) | EGFRALKZAP70INSRIGF1R | |
| SCHEMBL24327331 | 0.89 | EGFR (0.62) | EGFRALKZAP70INSRIGF1R | |
| SCHEMBL24327480 | 0.89 | EGFR (0.57) | EGFRALKZAP70INSRIGF1R | |
| SCHEMBL24327578 | 0.88 | EGFR (0.62) | EGFRALKZAP70INSRIGF1R | |
| SCHEMBL30141622 | 0.88 | EGFR (0.72) | EGFRALKZAP70INSRIGF1R | |
| SCHEMBL29216391 | 0.88 | EGFR (0.72) | EGFRALKZAP70INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063106-A1 | INDOLINE COMPOUNDS AND DERIVATIVES AS EGFR INHIBITORS | BEIGENE, LTD. (KY) | 2022-03-31 | — | — | WO | disclosed |