Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 4/20 | 0.37 |
| ▸ | TYK2 | P29597 | 4/20 | 0.37 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.36 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29498917 | 1.00 | FGFR1 (0.39) | FGFR1FGFR2FGFR3JAK2JAK1 | |
| SCHEMBL24327856 | 0.86 | EGFR (0.46) | FGFR1FGFR2FGFR3MAP4K3MAP3K12 | |
| SCHEMBL29498954 | 0.86 | EGFR (0.46) | FGFR1FGFR2FGFR3MAP4K3MAP3K12 | |
| SCHEMBL24328726 | 0.84 | MAP3K12 (0.37) | FGFR1FGFR2FGFR3JAK2JAK1 | |
| SCHEMBL24327976 | 0.75 | FGFR1 (0.52) | FGFR1FGFR2FGFR3MAP4K3EGFR | |
| SCHEMBL29498947 | 0.69 | MAPK1 (0.51) | FGFR1FGFR2FGFR3 | |
| SCHEMBL24327885 | 0.69 | MAPK1 (0.51) | FGFR1FGFR2FGFR3 | |
| SCHEMBL29498949 | 0.69 | FGFR3 (0.56) | FGFR1FGFR2FGFR3CDK1CCNB1 | |
| SCHEMBL24327350 | 0.69 | FGFR3 (0.56) | FGFR1FGFR2FGFR3CDK1CCNB1 | |
| SCHEMBL24327388 | 0.68 | FGFR3 (0.48) | FGFR1FGFR2FGFR3CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369097-B | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |