Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.35 |
| ▸ | JAK1 | P23458 | 7/20 | 0.35 |
| ▸ | TYK2 | P29597 | 7/20 | 0.35 |
| ▸ | JAK3 | P52333 | 7/20 | 0.35 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | MERTK | Q12866 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24327939 | 1.00 | JAK2 (0.35) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL29498925 | 0.91 | MERTK (0.34) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL29498918 | 0.79 | JAK2 (0.37) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL29498923 | 0.79 | JAK2 (0.36) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL29498964 | 0.79 | JAK2 (0.35) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL29601626 | 0.77 | JAK2 (0.34) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL29498928 | 0.73 | JAK1 (0.35) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL24539404 | 0.73 | JAK2 (0.35) | JAK2JAK1TYK2JAK3CNR1 | |
| SCHEMBL24327357 | 0.72 | JAK2 (0.39) | JAK2JAK1TYK2JAK3AXL | |
| SCHEMBL29600985 | 0.72 | JAK2 (0.34) | JAK2JAK1TYK2JAK3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114369097-B | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| WO-2022078356-A1 | HETEROAROMATIC AHR INHIBITOR | 山东轩竹医药科技有限公司 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369097-A | Heteroaromatic AhR inhibitors | 山东轩竹医药科技有限公司 | 2022-04-19 | — | — | CN | disclosed |