Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24317593 | 0.81 | CRBN (0.44) | — | |
| SCHEMBL24317401 | 0.64 | CRBN (0.46) | — | |
| SCHEMBL24317383 | 0.62 | CRBN (0.46) | — | |
| SCHEMBL29532547 | 0.61 | CRBN (0.46) | — | |
| SCHEMBL24317403 | 0.61 | CRBN (0.46) | — | |
| SCHEMBL24830140 | 0.61 | CRBN (0.50) | CDK5 | |
| SCHEMBL24663570 | 0.61 | MAPT (0.45) | CYP1B1 | |
| SCHEMBL24592089 | 0.60 | CRBN (0.55) | — | |
| SCHEMBL24779909 | 0.60 | DDB1 (0.43) | — | |
| SCHEMBL19526040 | 0.59 | DDB1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081928-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |