⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24673467 | 0.54 | — | — | |
| SCHEMBL14041529 | 0.54 | KDM4E (0.31) | — | |
| SCHEMBL25467540 | 0.47 | — | — | |
| SCHEMBL25467518 | 0.47 | — | — | |
| SCHEMBL5000976 | 0.46 | SMN1; SMN2 (0.46) | — | |
| SCHEMBL12588971 | 0.42 | INMT (0.33) | — | |
| SCHEMBL22211300 | 0.42 | — | — | |
| Hydrogen Peroxide SCHEMBL20915049 | 0.40 | TYR (0.55) | — | |
| SCHEMBL6947253 | 0.40 | — | — | |
| SCHEMBL3710809 | 0.39 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230372496-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2023-11-23 | — | — | US | disclosed |
| WO-2022081928-A1 | TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |