Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 3/20 | 0.68 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.68 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.68 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.43 |
| ▸ | GPR183 | P32249 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3321497 | 0.90 | PTGER2 (0.68) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2435853 | 0.90 | PTGER2 (0.82) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2440478 | 0.87 | PTGER2 (0.54) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2436389 | 0.83 | PTGER2 (0.61) | PTGER2PTGER4PTGDRNQO2PDE3B | |
| SCHEMBL2435130 | 0.83 | PTGER2 (0.59) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL5002721 | 0.82 | PTGER2 (0.71) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2436757 | 0.82 | PTGER2 (0.59) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2435225 | 0.82 | PTGER2 (0.58) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2432927 | 0.81 | PTGER2 (1.00) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2433396 | 0.79 | PTGER2 (0.67) | PTGER2PTGER4PTGDRDRD1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364296-A1 | PYRROLIDINES | Pfizer Limited (GB) | 2011-09-14 | — | — | EP | claimed |
| WO-2010052625-A1 | PYRROLIDINES | PFIZER LIMITED (GB) | 2010-05-14 | — | — | WO | claimed |
| EP-2364296-A1 | PYRROLIDINES | Pfizer Limited (GB) | 2011-09-14 | — | — | EP | disclosed |
| WO-2010052625-A1 | PYRROLIDINES | PFIZER LIMITED (GB) | 2010-05-14 | — | — | WO | disclosed |