Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER2 | P43116 | 3/20 | 0.68 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.68 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.68 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.41 |
| ▸ | TACR3 | P29371 | 2/20 | 0.40 |
| ▸ | GPR183 | P32249 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435853 | 0.91 | PTGER2 (0.82) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2433080 | 0.90 | PTGER2 (0.68) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2436757 | 0.90 | PTGER2 (0.59) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2435041 | 0.86 | PTGER2 (0.54) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL5002721 | 0.83 | PTGER2 (0.71) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2432927 | 0.81 | PTGER2 (1.00) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2472689 | 0.80 | PTGER2 (0.61) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2440478 | 0.80 | PTGER2 (0.54) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL2433396 | 0.79 | PTGER2 (0.67) | PTGER2PTGER4PTGDRDRD1HRH4 | |
| SCHEMBL5005602 | 0.79 | PTGER2 (0.82) | PTGER2PTGER4PTGDRDRD1HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278343-B2 | Pyrrolidines | PFIZER INC. (US) | 2012-10-02 | — | — | US | disclosed |
| WO-2010052625-A1 | PYRROLIDINES | PFIZER LIMITED (GB) | 2010-05-14 | — | — | WO | disclosed |
| US-20100120793-A1 | Pyrrolidines | PFIZER ANIMAL HEALTH UK 1 LIMITED (GB) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120793-A1 | Pyrrolidines | PTGER2, PTGDR2, PTGES2 | PTGER2 1/4885PTGER4 11/4885PTGDR 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.