SCHEMBL24330810

SCHEMBL24330810

O=C(O)CCc1nc2ccc(Br)cc2s1

nearest known ligand 0.68

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.68
ALOX15 P16050 1/20 0.54
HTT P42858 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
AKR1B1 P15121 4/20 0.51
RAB9A P51151 4/20 0.49
HPGD P15428 2/20 0.49
NPC1 O15118 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
DYRK1A Q13627 1/20 0.49
LIPG Q9Y5X9 1/20 0.48
PPARA Q07869 2/20 0.48
GAA P10253 1/20 0.44
MAPK1 P28482 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28125063 0.90 HDAC6 (0.53) HDAC6ALOX15HTTSMN1; SMN2AKR1B1
SCHEMBL2945307 0.88 HDAC6 (0.70) HDAC6ALOX15HTTSMN1; SMN2AKR1B1
SCHEMBL24332400 0.82 HDAC6 (0.68) HDAC6ALOX15HTTSMN1; SMN2AKR1B1
SCHEMBL24331728 0.82 HDAC6 (0.68) HDAC6ALOX15HTTSMN1; SMN2AKR1B1
SCHEMBL489018 0.81 RAB9A (0.47) HDAC6HTTSMN1; SMN2AKR1B1RAB9A
SCHEMBL1514591 0.81 HDAC6 (1.00) HDAC6ALOX15HTTSMN1; SMN2RAB9A
SCHEMBL24332388 0.80 HDAC6 (0.64) HDAC6ALOX15HTTSMN1; SMN2RAB9A
SCHEMBL24332164 0.79 HDAC6 (0.62) HDAC6ALOX15HTTSMN1; SMN2AKR1B1
SCHEMBL24332397 0.79 HDAC6 (0.62) HDAC6ALOX15HTTSMN1; SMN2RAB9A
SCHEMBL1269672 0.78 SMN1; SMN2 (0.82) HDAC6ALOX15HTTSMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3609876-B1 COVALENT SMALL MOLECULE DCN1 INHIBITORS AND THERAPEUTIC METHODS USING THE SAME UNIV MICHIGAN REGENTS (US) 2022-03-30 EP disclosed