Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.55 |
| ▸ | FLT1 | P17948 | 5/20 | 0.55 |
| ▸ | FLT4 | P35916 | 5/20 | 0.55 |
| ▸ | HCK | P08631 | 5/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.53 |
| ▸ | KIT | P10721 | 3/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.53 |
| ▸ | FES | P07332 | 2/20 | 0.53 |
| ▸ | FER | P16591 | 2/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | STK25 | O00506 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435234 | 0.94 | KDR (0.55) | KDRFLT1FLT4HCKMKNK2 | |
| SCHEMBL30151207 | 0.93 | KDR (0.57) | KDRFLT1FLT4HCKMKNK2 | |
| SCHEMBL2434456 | 0.93 | KDR (0.57) | KDRFLT1FLT4HCKMKNK2 | |
| SCHEMBL2433219 | 0.91 | KDR (0.54) | KDRFLT1FLT4HCKMKNK2 | |
| SCHEMBL274923 | 0.90 | KDR (0.53) | KDRFLT1FLT4HCKMKNK2 | |
| SCHEMBL2439239 | 0.90 | KDR (0.70) | KDRFLT1FLT4HCKMKNK2 | |
| SCHEMBL2435937 | 0.89 | KDR (0.52) | KDRFLT1FLT4HCKMKNK2 | |
| SCHEMBL279027 | 0.88 | KDR (0.53) | KDRFLT1FLT4HCKMKNK2 | |
| SCHEMBL2435727 | 0.86 | KDR (0.56) | KDRFLT1FLT4HCKMKNK2 | |
| SCHEMBL274004 | 0.86 | KDR (0.52) | KDRFLT1FLT4HCKMKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |