Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.70 |
| ▸ | FLT1 | P17948 | 6/20 | 0.70 |
| ▸ | FLT4 | P35916 | 6/20 | 0.70 |
| ▸ | HCK | P08631 | 2/20 | 0.54 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 4/20 | 0.52 |
| ▸ | RET | P07949 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK8 | P49336 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | STK25 | O00506 | 1/20 | 0.48 |
| ▸ | CIT | O14578 | 1/20 | 0.48 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2436227 | 0.92 | KDR (0.70) | KDRFLT1FLT4HCKNR2C2 | |
| SCHEMBL2433091 | 0.90 | KDR (0.55) | KDRFLT1FLT4HCKNR2C2 | |
| SCHEMBL2437280 | 0.90 | KDR (0.67) | KDRFLT1FLT4HCKNR2C2 | |
| SCHEMBL2435234 | 0.89 | KDR (0.55) | KDRFLT1FLT4HCKNR2C2 | |
| SCHEMBL4941049 | 0.84 | SRC (0.66) | KDRFLT1FLT4HCKNR2C2 | |
| SCHEMBL2435963 | 0.83 | KDR (1.00) | KDRFLT1FLT4KITRET | |
| SCHEMBL2465925 | 0.82 | KDR (0.65) | KDRFLT1FLT4HCKKIT | |
| SCHEMBL2434212 | 0.82 | SRC (0.59) | KDRFLT1FLT4HCKNR2C2 | |
| SCHEMBL2434456 | 0.82 | KDR (0.57) | KDRFLT1FLT4HCKNR2C2 | |
| SCHEMBL30151207 | 0.82 | KDR (0.57) | KDRFLT1FLT4HCKNR2C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |