Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469667 | 1.00 | KMT2A (0.36) | KMT2ANPC1RAB9AHRH1CCR3 | |
| SCHEMBL29469686 | 0.92 | NLRP3 (0.44) | KMT2ANLRP3ATMHTR7NR3C1 | |
| SCHEMBL24334273 | 0.92 | NLRP3 (0.44) | KMT2ANLRP3ATMHTR7NR3C1 | |
| SCHEMBL24333403 | 0.88 | KMT2A (0.35) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL29469648 | 0.86 | KMT2A (0.36) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL24334215 | 0.86 | KMT2A (0.37) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL31525463 | 0.85 | KAT6A (0.41) | KMT2AHRH1CCR3MAPTALDH1A1 | |
| SCHEMBL29469704 | 0.85 | PARP1 (0.33) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL24333951 | 0.84 | ALOX5AP (0.37) | KMT2ANPC1RAB9AMEN1MAPT | |
| SCHEMBL29469812 | 0.84 | ALOX5AP (0.37) | KMT2ANPC1RAB9AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |