Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.43 |
| ▸ | DCLK1 | O15075 | 15/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 12/20 | 0.43 |
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.43 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.43 |
| ▸ | DCLK2 | Q8N568 | 2/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.43 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24334577 | 0.90 | LRRK2 (0.57) | LRRK2DCLK1MAPK7BRD4TNK2 | |
| SCHEMBL24334047 | 0.86 | LRRK2 (0.44) | LRRK2DCLK1MAPK7BRD4TNK2 | |
| SCHEMBL24334856 | 0.86 | LRRK2 (0.54) | LRRK2DCLK1MAPK7BRD4TNK2 | |
| Hydrochloric Acid SCHEMBL30876812 | 0.86 | LRRK2 (0.43) | LRRK2DCLK1MAPK7BRD4TNK2 | |
| SCHEMBL24334546 | 0.85 | LRRK2 (0.53) | LRRK2DCLK1MAPK7BRD4TNK2 | |
| SCHEMBL24334761 | 0.83 | BRD4 (0.33) | LRRK2DCLK1MAPK7BRD4TNK2 | |
| SCHEMBL24334898 | 0.82 | LRRK2 (0.54) | LRRK2DCLK1MAPK7BRD4TNK2 | |
| SCHEMBL24334488 | 0.82 | LRRK2 (0.57) | LRRK2DCLK1MAPK7BRD4TNK2 | |
| SCHEMBL24334067 | 0.80 | LRRK2 (0.54) | LRRK2DCLK1MAPK7BRD4TNK2 | |
| SCHEMBL24334538 | 0.80 | LRRK2 (0.52) | LRRK2DCLK1MAPK7BRD4TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022078350-A1 | METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION | RANOK THERAPEUTICS (HANGZHOU) CO. LTD. (CN) | 2022-04-21 | — | — | WO | disclosed |