Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | PKLR | P30613 | 3/20 | 0.33 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469662 | 1.00 | POLB (0.39) | POLBTSHRUSP2LMNASMN1; SMN2 | |
| SCHEMBL24334001 | 0.89 | POLB (0.42) | POLBTSHRUSP2LMNASMN1; SMN2 | |
| SCHEMBL29469820 | 0.89 | POLB (0.42) | POLBTSHRUSP2LMNASMN1; SMN2 | |
| SCHEMBL29469614 | 0.84 | POLB (0.39) | POLBTSHRUSP2LMNASMN1; SMN2 | |
| SCHEMBL24334348 | 0.84 | POLB (0.39) | POLBTSHRUSP2LMNASMN1; SMN2 | |
| SCHEMBL24333584 | 0.84 | POLB (0.40) | POLBTSHRUSP2LMNASMN1; SMN2 | |
| SCHEMBL29469615 | 0.84 | POLB (0.40) | POLBTSHRUSP2LMNASMN1; SMN2 | |
| SCHEMBL24334341 | 0.83 | ALDH1A1 (0.38) | POLBTSHRUSP2LMNATP53 | |
| SCHEMBL24333785 | 0.83 | POLB (0.38) | POLBTSHRUSP2LMNASMN1; SMN2 | |
| SCHEMBL29469712 | 0.83 | POLB (0.38) | POLBTSHRUSP2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |