Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 14/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29385053 | 0.92 | KDM4E (0.65) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR2 | |
| SCHEMBL15413235 | 0.92 | KDM4E (0.65) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR2 | |
| Hydrochloric Acid SCHEMBL28010166 | 0.91 | KDM4E (0.63) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR2 | |
| SCHEMBL24336038 | 0.87 | FGFR1 (0.46) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR2 | |
| SCHEMBL29385006 | 0.80 | FGFR1 (0.55) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR2 | |
| SCHEMBL16667808 | 0.80 | FGFR1 (0.55) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR2 | |
| SCHEMBL18612966 | 0.80 | CYP11B1 (0.49) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR2 | |
| SCHEMBL20331733 | 0.80 | NPC1 (0.51) | KDM4EALDH1A1SMN1; SMN2FGFR1CYP11B1 | |
| SCHEMBL16668439 | 0.78 | FGFR1 (0.52) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR2 | |
| SCHEMBL31647846 | 0.78 | FGFR1 (0.59) | KDM4EALDH1A1SMN1; SMN2FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3395814-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2022-04-06 | — | — | EP | disclosed |