Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | XDH | P47989 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27802722 | 0.87 | NOTUM (0.53) | NOTUMCA12CA1CA2CA7 | |
| SCHEMBL1495777 | 0.79 | NOTUM (0.49) | NOTUMCA12CA1CA2CA7 | |
| Methyl 3,5-Dibromobenzoate SCHEMBL2408987 | 0.78 | NOTUM (0.67) | NOTUMCA12CA1CA2CA7 | |
| SCHEMBL184614 | 0.78 | NOTUM (0.67) | NOTUMCA12CA1CA2CA7 | |
| SCHEMBL26334405 | 0.78 | NOTUM (0.48) | NOTUMCA12CA1CA2CA7 | |
| SCHEMBL1495639 | 0.78 | NOTUM (0.59) | NOTUMCA12CA1CA2CA7 | |
| SCHEMBL22926213 | 0.78 | NOTUM (0.51) | NOTUMCA12CA1CA2CA7 | |
| SCHEMBL22400614 | 0.77 | NOTUM (0.50) | NOTUMCA12CA1CA2CA7 | |
| SCHEMBL25369527 | 0.77 | NOTUM (0.47) | NOTUMCA12CA1CA2CA7 | |
| SCHEMBL1495771 | 0.75 | NOTUM (0.44) | NOTUMCA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022066864-A1 | SHMT INHIBITORS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2022-03-31 | — | — | WO | disclosed |