Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 15/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14667128 | 0.86 | MAPK8 (0.58) | MAPK8MAPK9RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL30873307 | 0.86 | MAPK8 (0.54) | MAPK8MAPK9POLBALDH1A1CDK1 | |
| SCHEMBL14657249 | 0.86 | MAPK8 (0.54) | MAPK8MAPK9POLBALDH1A1CDK1 | |
| SCHEMBL14657251 | 0.86 | MAPK8 (0.54) | MAPK8MAPK9POLBALDH1A1CDK1 | |
| SCHEMBL24340547 | 0.83 | MAPK8 (0.49) | MAPK8MAPK9POLBCDK1CDK4 | |
| SCHEMBL29501909 | 0.79 | NR2F2 (0.52) | MAPK8MAPK9RAB9ANPSR1NPC1 | |
| SCHEMBL26159745 | 0.79 | NR2F2 (0.52) | MAPK8MAPK9RAB9ANPSR1NPC1 | |
| SCHEMBL26159741 | 0.79 | NR2F2 (0.52) | MAPK8MAPK9RAB9ANPSR1NPC1 | |
| SCHEMBL20299403 | 0.79 | NR2F2 (0.52) | MAPK8MAPK9RAB9ANPSR1NPC1 | |
| SCHEMBL29501912 | 0.79 | NR2F2 (0.52) | MAPK8MAPK9RAB9ANPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022048684-A1 | JNK INHIBITOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 武汉朗来科技发展有限公司 | 2022-03-10 | — | — | WO | disclosed |