Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 15/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CCND1 | P24385 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14657249 | 1.00 | MAPK8 (0.54) | MAPK8MAPK9POLBCDK1CDK4 | |
| SCHEMBL14657251 | 1.00 | MAPK8 (0.54) | MAPK8MAPK9POLBCDK1CDK4 | |
| SCHEMBL24340552 | 0.86 | MAPK8 (0.55) | MAPK8MAPK9POLBCDK1CDK4 | |
| SCHEMBL14657230 | 0.86 | MAPK8 (0.58) | MAPK8MAPK9 | |
| SCHEMBL14657231 | 0.86 | MAPK8 (0.58) | MAPK8MAPK9 | |
| SCHEMBL14657649 | 0.85 | MAPK8 (0.69) | MAPK8MAPK9 | |
| SCHEMBL14657650 | 0.85 | MAPK8 (0.69) | MAPK8MAPK9 | |
| SCHEMBL24340547 | 0.79 | MAPK8 (0.49) | MAPK8MAPK9POLBCDK1CDK4 | |
| SCHEMBL28448559 | 0.77 | MAPK8 (0.51) | MAPK8MAPK9 | |
| SCHEMBL29501912 | 0.76 | NR2F2 (0.52) | MAPK8MAPK9POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111471021-B | Substituted diamino carboxamides and diamino carbonitrile pyrimidines, compositions thereof, and methods of treatment therewith | 西格诺药品有限公司 | 2024-04-02 | — | — | CN | disclosed |