Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2433250 | 0.88 | KDR (0.60) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2434322 | 0.86 | KDR (0.51) | KDRNTRK1FLT1FLT4RET | |
| SCHEMBL2434130 | 0.86 | KDR (0.45) | KDRFLT1FLT4BRAFCDK8 | |
| SCHEMBL2437406 | 0.84 | KDR (0.63) | KDRFLT1FLT4BRAFMAPK14 | |
| SCHEMBL12972298 | 0.84 | KDR (0.61) | KDRNTRK1FLT1FLT4RET | |
| SCHEMBL12972249 | 0.82 | KDR (0.58) | KDRNTRK1FLT1FLT4RET | |
| SCHEMBL2433982 | 0.80 | KDR (0.58) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2433093 | 0.79 | KDR (0.64) | KDRBRAFMAPK14TNNI3K | |
| SCHEMBL2707864 | 0.79 | MEN1 (0.49) | KDRLMNALCKMETTEK | |
| SCHEMBL2435262 | 0.77 | TRPV1 (0.48) | TRPV1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |