Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.63 |
| ▸ | BRAF | P15056 | 13/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.63 |
| ▸ | TNNI3K | Q59H18 | 12/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435957 | 0.92 | KDR (0.62) | KDRBRAFMAPK14TNNI3KFLT1 | |
| SCHEMBL2434322 | 0.91 | KDR (0.51) | KDRBRAFMAPK14TNNI3KFLT1 | |
| SCHEMBL2433093 | 0.88 | KDR (0.64) | KDRBRAFMAPK14TNNI3K | |
| SCHEMBL2433250 | 0.86 | KDR (0.60) | KDRBRAFMAPK14TNNI3KFLT1 | |
| SCHEMBL2435966 | 0.86 | KDR (0.57) | KDRBRAFMAPK14TNNI3KFLT1 | |
| SCHEMBL2434342 | 0.84 | KDR (0.60) | KDRBRAFMAPK14TNNI3KFLT1 | |
| SCHEMBL12972237 | 0.82 | KDR (0.62) | KDRBRAFMAPK14TNNI3KFLT1 | |
| SCHEMBL12972263 | 0.82 | KDR (0.62) | KDRBRAFMAPK14TNNI3KFLT1 | |
| SCHEMBL4282402 | 0.81 | KDR (0.57) | KDRBRAFMAPK14TNNI3KFLT1 | |
| SCHEMBL10261459 | 0.80 | KDR (0.52) | KDRBRAFMAPK14TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |