Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
| ▸ | UBE2N | P61088 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20442004 | 0.71 | KMT2A (0.47) | KMT2APOLBHTTALDH1A1HPGD | |
| SCHEMBL24343792 | 0.69 | KMT2A (0.45) | KMT2APOLBHTTALDH1A1PKM | |
| SCHEMBL24666975 | 0.69 | ALDH1A1 (0.33) | ALDH1A1PKM | |
| SCHEMBL246975 | 0.68 | POLB (0.48) | KMT2APOLBHTTALDH1A1PKM | |
| SCHEMBL29300135 | 0.68 | TSHR (0.35) | — | |
| SCHEMBL24992694 | 0.68 | KMT2A (0.40) | KMT2APOLBHTTALDH1A1HPGD | |
| SCHEMBL20442848 | 0.67 | KMT2A (0.39) | KMT2APOLBHTTALDH1A1PKM | |
| SCHEMBL20967313 | 0.66 | POLB (0.33) | KMT2APOLBHTT | |
| SCHEMBL19594793 | 0.66 | POLB (0.35) | KMT2APOLBHTTALDH1A1HPGD | |
| SCHEMBL3719107 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076975-A1 | 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |