Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 17/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246727 | 0.89 | KLKB1 (0.59) | KLKB1 | |
| SCHEMBL370508 | 0.88 | KMT2A (0.53) | KLKB1KMT2ARAB9A | |
| SCHEMBL31352698 | 0.84 | KLKB1 (0.44) | KLKB1KMT2A | |
| SCHEMBL17786881 | 0.84 | KLKB1 (0.64) | KLKB1 | |
| SCHEMBL17786993 | 0.83 | KLKB1 (0.52) | KLKB1 | |
| SCHEMBL17787030 | 0.81 | KLKB1 (0.46) | KLKB1 | |
| SCHEMBL17784852 | 0.81 | KLKB1 (0.67) | KLKB1 | |
| SCHEMBL22491808 | 0.80 | KLKB1 (0.64) | KLKB1 | |
| SCHEMBL26227498 | 0.79 | F11 (0.44) | KLKB1RAB9A | |
| SCHEMBL16246944 | 0.78 | KLKB1 (0.55) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022079446-A1 | TREATMENTS OF ANGIOEDEMA | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2022-04-21 | — | — | WO | disclosed |