Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434434 | 1.00 | MAPT (0.39) | MAPTACKR3KDM4EHTTATM | |
| SCHEMBL2436046 | 0.94 | ALDH1A1 (0.38) | MAPTACKR3KDM4EHTTATM | |
| SCHEMBL2436051 | 0.94 | ALDH1A1 (0.38) | MAPTACKR3KDM4EHTTATM | |
| SCHEMBL2429970 | 0.93 | S1PR1 (0.36) | MAPTACKR3KDM4EHTTATM | |
| SCHEMBL2429967 | 0.93 | S1PR1 (0.36) | MAPTACKR3KDM4EHTTATM | |
| SCHEMBL2430873 | 0.92 | ACKR3 (0.38) | ACKR3SMYD3CDK9EZH2P2RX3 | |
| SCHEMBL2430867 | 0.92 | ACKR3 (0.38) | ACKR3SMYD3CDK9EZH2P2RX3 | |
| SCHEMBL2429886 | 0.89 | ACKR3 (0.36) | MAPTACKR3KDM4EHTTATM | |
| SCHEMBL2429880 | 0.89 | ACKR3 (0.36) | MAPTACKR3KDM4EHTTATM | |
| SCHEMBL2432544 | 0.88 | ALDH1A1 (0.38) | ACKR3KDM4EHTTATMSMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086966-B1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-09-14 | — | — | EP | disclosed |