Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434440 | 1.00 | RAB9A (0.44) | RAB9ASMN1; SMN2KMT2AJAK1NPC1 | |
| SCHEMBL2430828 | 0.92 | SMN1; SMN2 (0.42) | RAB9ASMN1; SMN2KMT2AJAK1NPC1 | |
| SCHEMBL2430826 | 0.92 | SMN1; SMN2 (0.42) | RAB9ASMN1; SMN2KMT2AJAK1NPC1 | |
| SCHEMBL4341749 | 0.92 | KMT2A (0.42) | RAB9ASMN1; SMN2KMT2ANPC1ALDH1A1 | |
| SCHEMBL4341753 | 0.92 | KMT2A (0.42) | RAB9ASMN1; SMN2KMT2ANPC1ALDH1A1 | |
| SCHEMBL2432670 | 0.91 | PTPN1 (0.46) | RAB9ASMN1; SMN2JAK1NPC1HPGD | |
| SCHEMBL2432673 | 0.91 | PTPN1 (0.46) | RAB9ASMN1; SMN2JAK1NPC1HPGD | |
| SCHEMBL2431091 | 0.90 | GRM4 (0.39) | RAB9ANPC1HPGDTP53MAPT | |
| SCHEMBL2431089 | 0.90 | GRM4 (0.39) | RAB9ANPC1HPGDTP53MAPT | |
| SCHEMBL2431283 | 0.88 | GRM4 (0.38) | RAB9ANPC1HPGDTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086966-B1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-09-14 | — | — | EP | disclosed |
| US-20090274655-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS | SMITHKLINE BEECHAM CORPORATION | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090274655-A1 | 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS | EIF2AK2, HAVCR2, GTF3C2 | RAB9A 2071/4885SMN1; SMN2 1772/4885KMT2A 2967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.