Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.48 |
| ▸ | KIT | P10721 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL740932 | 0.88 | AURKA (0.53) | AURKAKITFLT3FGFR1KDR | |
| SCHEMBL4632688 | 0.84 | AURKA (0.51) | AURKAKITFLT3FGFR1KDR | |
| SCHEMBL2431925 | 0.84 | KIT (0.47) | AURKAKITFLT3FGFR1KDR | |
| SCHEMBL2432693 | 0.83 | LRRK2 (0.46) | AURKAKITFLT3FGFR1KDR | |
| SCHEMBL2432386 | 0.83 | AURKA (0.47) | AURKAKITFLT3FGFR1KDR | |
| SCHEMBL2433100 | 0.81 | ABL1 (0.52) | AURKAKITFLT3ABL1BCR | |
| SCHEMBL740471 | 0.81 | AURKA (0.62) | AURKAKITFLT3ABL1BCR | |
| SCHEMBL741251 | 0.80 | AURKA (0.64) | AURKAKITFLT3FGFR1KDR | |
| SCHEMBL2433592 | 0.79 | AURKA (0.46) | AURKAKITFLT3FGFR1KDR | |
| SCHEMBL4086831 | 0.78 | AURKA (0.54) | AURKAKITFLT3FGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007380-B1 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2011-09-14 | — | — | EP | claimed |