Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 13/20 | 0.54 |
| ▸ | KIT | P10721 | 5/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PRKCB | P05771 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.47 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088635 | 0.93 | AURKA (0.58) | AURKAKITFLT3 | |
| SCHEMBL4081182 | 0.89 | AURKA (0.61) | AURKAKITFLT3NTRK1KDR | |
| SCHEMBL4086381 | 0.86 | FLT3 (0.42) | AURKAFLT3NTRK1CDC7PAK4 | |
| SCHEMBL3881571 | 0.82 | AURKA (0.61) | AURKAKITFLT3NTRK1KDR | |
| SCHEMBL3882930 | 0.82 | AURKA (0.62) | AURKAKITFLT3NTRK1KDR | |
| SCHEMBL4086497 | 0.82 | AURKA (0.71) | AURKAKITFLT3 | |
| SCHEMBL740932 | 0.82 | AURKA (0.53) | AURKAKITFLT3NTRK1KDR | |
| SCHEMBL4081465 | 0.81 | ABL1 (0.54) | AURKAFLT3KDR | |
| SCHEMBL4078233 | 0.79 | AURKA (0.54) | AURKAKITFLT3NTRK1KDR | |
| SCHEMBL4086290 | 0.79 | MAPT (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |