Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | LITAF | Q99732 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24344633 | 0.74 | MAPT (0.34) | LMNAKDM4EALDH1A1HPGDTP53 | |
| SCHEMBL24344624 | 0.73 | LMNA (0.30) | LMNA | |
| SCHEMBL19361118 | 0.72 | AURKA (0.36) | LMNATP53 | |
| SCHEMBL24344043 | 0.72 | CCNE1 (0.31) | CCNE1CDK2CNR2GPR55 | |
| SCHEMBL10027311 | 0.71 | MAPT (0.36) | LMNAKDM4EALDH1A1GAAHPGD | |
| SCHEMBL24344358 | 0.70 | — | — | |
| SCHEMBL24345054 | 0.70 | MAPT (0.35) | LMNAKDM4EALDH1A1HPGDTP53 | |
| SCHEMBL10027189 | 0.70 | LMNA (0.34) | LMNATP53 | |
| SCHEMBL10027291 | 0.70 | MAPT (0.36) | LMNATP53 | |
| SCHEMBL17808794 | 0.69 | JAK2 (0.39) | LMNAKDM4EALDH1A1GAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227292-B1 | 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUNDS | ALTERITY THERAPEUTICS LTD (AU) | 2022-03-09 | — | — | EP | disclosed |