Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 7/20 | 0.33 |
| ▸ | CNR1 | P21554 | 4/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17808786 | 0.83 | HSD17B10 (0.46) | KDM4EALDH1A1CYP1A2GLAGAA | |
| SCHEMBL24345095 | 0.81 | CHEK1 (0.34) | PLAT | |
| SCHEMBL24345069 | 0.73 | HSD17B10 (0.47) | KDM4EALDH1A1GLAGAACYP2D6 | |
| SCHEMBL17808743 | 0.73 | CYP2C9 (0.44) | KDM4EALDH1A1GAACYP2D6HPGD | |
| SCHEMBL17808907 | 0.72 | CYP2C9 (0.43) | KDM4EALDH1A1GLAGAACYP2D6 | |
| SCHEMBL24345058 | 0.71 | — | — | |
| SCHEMBL24344662 | 0.70 | — | — | |
| SCHEMBL17808789 | 0.67 | CYP2C9 (0.47) | KDM4EALDH1A1GAACYP2D6CYP2C19 | |
| SCHEMBL24345051 | 0.66 | TP53 (0.33) | KDM4EALDH1A1MAPTCNR2CNR1 | |
| SCHEMBL24344175 | 0.65 | CCNE1 (0.35) | PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227292-B1 | 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUNDS | ALTERITY THERAPEUTICS LTD (AU) | 2022-03-09 | — | — | EP | disclosed |