Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 7/20 | 0.35 |
| ▸ | CDK2 | P24941 | 7/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17802288 | 0.86 | CDK9 (0.47) | CCNE1CDK2CDK9CHEK1AURKA | |
| SCHEMBL17808731 | 0.85 | CDK9 (0.46) | CCNE1CDK2CDK9CHEK1AURKA | |
| SCHEMBL24344137 | 0.85 | CHEK1 (0.34) | CDK9CHEK1AURKADAPK3JAK2 | |
| SCHEMBL24345095 | 0.84 | CHEK1 (0.34) | CCNE1CDK2CDK9CHEK1AURKA | |
| SCHEMBL24345092 | 0.81 | ALDH1A1 (0.41) | ACVR1 | |
| SCHEMBL24344150 | 0.80 | ALDH1A1 (0.41) | ACVR1 | |
| SCHEMBL24344399 | 0.77 | GRM2 (0.38) | FYNRETKDRBTKCLK4 | |
| SCHEMBL24345063 | 0.71 | CCNE1 (0.39) | CCNE1CDK2CDK9CCNT1CDK1 | |
| SCHEMBL17808769 | 0.68 | CCNE1 (0.41) | CCNE1CDK2CDK9CCNT1CDK1 | |
| SCHEMBL17802284 | 0.67 | CCNE1 (0.42) | CCNE1CDK2CDK9CCNT1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227292-B1 | 4H-PYRIDO[1,2-a]PYRIMIDIN-4-ONE COMPOUNDS | ALTERITY THERAPEUTICS LTD (AU) | 2022-03-09 | — | — | EP | disclosed |