Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 13/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BPTF | Q12830 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2434184 | 0.98 | AURKA (0.40) | AURKAPTK6ADRA2AADRA2BADRA2C | |
| SCHEMBL2438052 | 0.85 | AURKA (0.46) | AURKA | |
| SCHEMBL2442013 | 0.84 | PTK6 (0.41) | AURKAPTK6KDM4E | |
| SCHEMBL405018 | 0.80 | CREBBP (0.49) | AURKAPTK6 | |
| SCHEMBL407556 | 0.79 | BAZ2B (0.47) | PTK6 | |
| SCHEMBL407479 | 0.75 | AURKA (0.46) | AURKAPTK6ADRA2AADRA2BADRA2C | |
| SCHEMBL407464 | 0.73 | AURKA (0.46) | AURKAPTK6ADRA2AADRA2BADRA2C | |
| SCHEMBL3707014 | 0.67 | AURKA (0.49) | AURKAPTK6 | |
| SCHEMBL407376 | 0.65 | BAZ2B (0.47) | — | |
| SCHEMBL407838 | 0.65 | BAZ2B (0.46) | AURKAPTK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367822-A1 | TRICYCLIC AZAINDOLES | Merck Patent GmbH (DE) | 2011-09-28 | — | — | EP | claimed |
| WO-2010080253-A1 | TRICYCLIC AZAINDOLES | MERCK PATENT GMBH (DE) | 2010-07-15 | — | — | WO | claimed |