Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 14/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2438052 | 0.87 | AURKA (0.46) | AURKA | |
| SCHEMBL2434184 | 0.84 | AURKA (0.40) | PTK6AURKAKDM4E | |
| SCHEMBL2434736 | 0.84 | AURKA (0.40) | PTK6AURKAKDM4E | |
| SCHEMBL407838 | 0.82 | BAZ2B (0.46) | PTK6AURKAMAPT | |
| SCHEMBL408059 | 0.76 | AURKA (0.49) | PTK6AURKA | |
| Hydrochloric Acid SCHEMBL403430 | 0.75 | AURKA (0.49) | PTK6AURKA | |
| SCHEMBL405109 | 0.69 | CREBBP (0.59) | AURKAMAPT | |
| SCHEMBL407222 | 0.68 | CREBBP (0.61) | AURKAMAPT | |
| SCHEMBL407376 | 0.66 | BAZ2B (0.47) | MAPT | |
| SCHEMBL407556 | 0.66 | BAZ2B (0.47) | PTK6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367822-A1 | TRICYCLIC AZAINDOLES | Merck Patent GmbH (DE) | 2011-09-28 | — | — | EP | claimed |
| WO-2010080253-A1 | TRICYCLIC AZAINDOLES | MERCK PATENT GMBH (DE) | 2010-07-15 | — | — | WO | claimed |