Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21172956 | 0.84 | HTT (0.51) | NAMPTHPGDKMT2AKDM4E | |
| SCHEMBL21173127 | 0.83 | MAPT (0.40) | HPGDBRD4 | |
| SCHEMBL21173212 | 0.79 | TDP1 (0.43) | HPGDBRD4KDM4E | |
| SCHEMBL21172814 | 0.79 | TDP1 (0.43) | HPGDBRD4KDM4E | |
| SCHEMBL21173006 | 0.78 | KDM4E (0.43) | HPGDBRD4KDM4E | |
| SCHEMBL21172659 | 0.78 | KDM4E (0.43) | HPGDBRD4KDM4E | |
| SCHEMBL21172932 | 0.77 | NAMPT (0.42) | NAMPTPRMT5HPGDACSS2MEN1 | |
| SCHEMBL21173162 | 0.76 | SRD5A1 (0.43) | HPGDKDM4E | |
| SCHEMBL21172697 | 0.75 | BRD4 (0.46) | HPGDBRD4 | |
| SCHEMBL21173170 | 0.75 | BRD4 (0.46) | HPGDBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511323-B1 | 2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2022-03-02 | — | — | EP | disclosed |