Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPGM | P07738 | 3/20 | 0.65 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24348428 | 0.88 | BPGM (0.75) | BPGMPIK3CGKDM4EMAPTHTT | |
| SCHEMBL24348923 | 0.87 | BPGM (0.60) | BPGMTGFBR1PIK3CGKDM4EMAPT | |
| SCHEMBL24349274 | 0.86 | BPGM (0.63) | BPGMTGFBR1PIK3CGKDM4EMAPT | |
| SCHEMBL24348548 | 0.82 | BPGM (0.77) | BPGMPIK3CGKDM4EMAPTHTT | |
| SCHEMBL24349409 | 0.82 | BPGM (0.66) | BPGMPIK3CGKDM4EMAPTHTT | |
| SCHEMBL24271952 | 0.80 | BPGM (0.68) | BPGMPIK3CGKDM4EMAPTHTT | |
| SCHEMBL24348943 | 0.79 | BPGM (0.67) | BPGMPIK3CGKDM4EMAPTHTT | |
| SCHEMBL24348481 | 0.78 | BPGM (0.49) | BPGMPIK3CGKDM4EMAPTHTT | |
| SCHEMBL24348948 | 0.77 | BPGM (0.73) | BPGMPIK3CGKDM4EMAPTHTT | |
| SCHEMBL24348944 | 0.76 | BPGM (0.68) | BPGMTGFBR1PIK3CGMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022056449-A1 | COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE | GENZYME CORPORATION (US) | 2022-03-17 | — | — | WO | disclosed |