Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPGM | P07738 | 6/20 | 0.52 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 9/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | MARK3 | P27448 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24349408 | 0.90 | BPGM (0.64) | BPGMPPARDKDM4ECDC7PLK4 | |
| SCHEMBL24348054 | 0.88 | BPGM (0.55) | BPGMPPARDKDM4ECDC7PLK4 | |
| SCHEMBL26704310 | 0.88 | BPGM (0.46) | BPGMGPR52PPARDKDM4ECDC7 | |
| SCHEMBL24348056 | 0.87 | BPGM (0.54) | BPGMKDM4ECDC7PLK4DYRK3 | |
| SCHEMBL24348060 | 0.87 | BPGM (0.54) | BPGMPPARDKDM4ECDC7PLK4 | |
| SCHEMBL24348977 | 0.87 | BPGM (0.54) | BPGMKDM4ECDC7PLK4DYRK3 | |
| SCHEMBL26704320 | 0.85 | BPGM (0.61) | BPGMGPR52PPARDMRGPRX4PTGER4 | |
| SCHEMBL24349278 | 0.83 | BPGM (0.44) | BPGMGPR52PPARDKDM4ECDC7 | |
| SCHEMBL24349263 | 0.83 | BPGM (0.49) | BPGMKDM4ECDC7PLK4DYRK3 | |
| SCHEMBL24349240 | 0.82 | BPGM (0.47) | BPGMGPR52PPARDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022056449-A1 | COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE | GENZYME CORPORATION (US) | 2022-03-17 | — | — | WO | disclosed |