SCHEMBL24348989

SCHEMBL24348989

Cc1cc(-c2cnc(NCc3ccc(F)cc3)nc2C2CCC2)on1

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TMEM97 Q5BJF2 12/20 0.44
SIGMAR1 Q99720 6/20 0.44
PRKAB2 O43741 6/20 0.43
PRKAG1 P54619 6/20 0.43
PRKAA2 P54646 6/20 0.43
PRKAA1 Q13131 6/20 0.43
PRKAG3 Q9UGI9 6/20 0.43
PRKAG2 Q9UGJ0 6/20 0.43
PRKAB1 Q9Y478 6/20 0.43
PDE2A O00408 1/20 0.43
KCNH2 Q12809 3/20 0.41
NTRK1 P04629 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24348328 0.96 TMEM97 (0.46) TMEM97SIGMAR1PRKAB2PRKAG1PRKAA2
SCHEMBL24348472 0.85 PDE2A (0.46) TMEM97SIGMAR1PRKAB2PRKAG1PRKAA2
SCHEMBL24348476 0.85 TMEM97 (0.46) TMEM97SIGMAR1PRKAB2PRKAG1PRKAA2
SCHEMBL24348437 0.83 MEN1 (0.43) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL24349664 0.80 IGF1R (0.47) TMEM97SIGMAR1PRKAB2PRKAG1PRKAA2
SCHEMBL24349631 0.80 MEN1 (0.41) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL24348478 0.80 MEN1 (0.41) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL24348479 0.80 PDE2A (0.46) TMEM97SIGMAR1PRKAB2PRKAG1PRKAA2
SCHEMBL24348435 0.79 KDM4E (0.48) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3
SCHEMBL24348470 0.79 MEN1 (0.40) PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230329236-A1 HERBICIDAL PYRIMIDINE DERIVATIVES MOA Technology Limited (GB) 2023-10-19 US disclosed
US-20230329236-A1 HERBICIDAL PYRIMIDINE DERIVATIVES MOA Technology Limited (GB) 2023-10-19 US disclosed
WO-2022053803-A1 HERBICIDAL PYRIMIDINE DERIVATIVES MOA Technology Limited (GB) 2022-03-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230329236-A1 HERBICIDAL PYRIMIDINE DERIVATIVES DPYD, XDH, DHX35 TMEM97 3314/4885SIGMAR1 1251/4885PRKAB2 3755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.