Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.62 |
| ▸ | FLT1 | P17948 | 5/20 | 0.58 |
| ▸ | FLT4 | P35916 | 5/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 4/20 | 0.51 |
| ▸ | RAF1 | P04049 | 3/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.47 |
| ▸ | STK25 | O00506 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | MUSK | O15146 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL274622 | 0.84 | KDR (0.63) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2437330 | 0.84 | KDR (0.84) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL274614 | 0.82 | KDR (0.60) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL274497 | 0.81 | KDR (0.57) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL273545 | 0.80 | KDR (0.58) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL278849 | 0.80 | KDR (0.58) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL273272 | 0.80 | KDR (0.58) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL274221 | 0.79 | KDR (0.56) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL279328 | 0.79 | KDR (0.56) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL273571 | 0.79 | KDR (0.54) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |