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SCHEMBL2435271

SCHEMBL2435271

O=C(Nc1cccc(C(F)(F)F)c1)c1cccc2cc(Oc3cc(CCl)ncn3)ccc12

nearest known ligand 0.85

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 19/20 0.85
▸ FLT1 P17948 5/20 0.85
▸ FLT4 P35916 5/20 0.85
▸ RET P07949 2/20 0.85
▸ PDGFRB P09619 2/20 0.85
▸ KIT P10721 2/20 0.85
▸ MAPK14 Q16539 3/20 0.50
▸ TNNI3K Q59H18 3/20 0.50
▸ BRAF P15056 2/20 0.50
▸ RXFP1 Q9HBX9 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bfh-772 SCHEMBL29366190 0.92 KDR (1.00) KDRFLT1FLT4RETPDGFRB
Bfh-772 SCHEMBL987715 0.92 KDR (1.00) KDRFLT1FLT4RETPDGFRB
Bfh-772 SCHEMBL1041162 0.91 KDR (0.98) KDRFLT1FLT4RETPDGFRB
SCHEMBL2434211 0.91 KDR (0.85) KDRFLT1FLT4RETPDGFRB
SCHEMBL2439589 0.90 KDR (0.83) KDRFLT1FLT4RETPDGFRB
SCHEMBL2468872 0.90 KDR (0.83) KDRFLT1FLT4RETPDGFRB
SCHEMBL989240 0.89 KDR (0.82) KDRFLT1FLT4RETPDGFRB
SCHEMBL2437180 0.89 KDR (0.81) KDRFLT1FLT4RETPDGFRB
SCHEMBL2438656 0.89 KDR (0.81) KDRFLT1FLT4RETPDGFRB
SCHEMBL1875161 0.88 KDR (0.80) KDRFLT1FLT4RETPDGFRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8026247-B2 Bicyclic amides as kinase inhibitors NOVARTIS AG (CH) 2011-09-27 — — US disclosed