Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | FLT1 | P17948 | 3/20 | 0.56 |
| ▸ | FLT4 | P35916 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.53 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.48 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439076 | 0.89 | KDR (0.68) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2432219 | 0.83 | KDR (0.70) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2433812 | 0.83 | RXFP1 (0.54) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL5740671 | 0.81 | KDR (0.82) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2747717 | 0.81 | KDR (0.82) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2433575 | 0.78 | PTPN1 (0.47) | KDRMEN1KMT2A | |
| SCHEMBL987105 | 0.75 | RXFP1 (0.72) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL27652617 | 0.75 | RXFP1 (0.88) | RXFP1P2RX1P2RX4P2RX7PTGS1 | |
| SCHEMBL2435904 | 0.74 | KDR (0.70) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2439211 | 0.73 | KDR (0.72) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |