Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 3/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 2/20 | 0.31 |
| ▸ | MMP9 | P14780 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24359869 | 1.00 | ACE (0.38) | ACEMMEACE2KDM4EMAPT | |
| SCHEMBL24360274 | 1.00 | ACE (0.38) | ACEMMEACE2KDM4EMAPT | |
| SCHEMBL23197955 | 0.83 | ACE (0.34) | ACEKDM4EMAPTTHRBALOX15 | |
| SCHEMBL21666433 | 0.83 | MMP1 (0.45) | ACEMMEACE2KDM4ESMN1; SMN2 | |
| SCHEMBL24668403 | 0.79 | CA1 (0.37) | ACEMMEACE2KDM4EMAPT | |
| SCHEMBL24669397 | 0.79 | CA1 (0.37) | ACEMMEACE2KDM4EMAPT | |
| SCHEMBL24668419 | 0.79 | CA1 (0.37) | ACEMMEACE2KDM4EMAPT | |
| SCHEMBL20968348 | 0.77 | ACE (0.39) | ACEMMEACE2MAPTNFKB1 | |
| SCHEMBL24378316 | 0.75 | KDM4E (0.44) | ACEMMEACE2KDM4EMAPT | |
| SCHEMBL24668382 | 0.75 | ANPEP (0.37) | ACEMMEACE2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022084739-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF OCULAR DISORDERS | Azura Ophthalmics Ltd. (IL) | 2022-04-28 | — | — | WO | disclosed |