Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29632130 | 1.00 | GRM5 (0.51) | GRM5MCHR1ADRA2AIGF1RNPC1 | |
| SCHEMBL25111637 | 0.92 | GRM5 (0.61) | GRM5HCRTR1MAPK1CXCR6KMT2A | |
| SCHEMBL29522790 | 0.92 | GRM5 (0.61) | GRM5HCRTR1MAPK1CXCR6KMT2A | |
| SCHEMBL29632111 | 0.92 | MCHR1 (0.45) | GRM5MCHR1ADRA2AIGF1RNPC1 | |
| SCHEMBL24360078 | 0.92 | MCHR1 (0.45) | GRM5MCHR1ADRA2AIGF1RNPC1 | |
| SCHEMBL24360028 | 0.91 | MCHR1 (0.47) | GRM5MCHR1ADRA2AIGF1RNPC1 | |
| SCHEMBL29632072 | 0.91 | MCHR1 (0.47) | GRM5MCHR1ADRA2AIGF1RNPC1 | |
| SCHEMBL24360019 | 0.91 | GRM5 (0.46) | GRM5MCHR1ADRA2AIGF1RKMT2A | |
| SCHEMBL29632043 | 0.91 | GRM5 (0.46) | GRM5MCHR1ADRA2AIGF1RKMT2A | |
| SCHEMBL24360027 | 0.90 | MCHR1 (0.55) | MCHR1ADRA2AIGF1RNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12384748-B2 | Modulators of mas-related g-protein receptor X2 and related products and methods | ESCIENT PHARMACEUTICALS, INC. (US) | 2025-08-12 | — | — | US | disclosed |
| US-20240351987-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS INC (US) | 2024-10-24 | — | — | US | disclosed |
| US-11970452-B2 | Modulators of mas-related G-protein receptor X2 and related products and methods | ESCIENT PHARMACEUTICALS, INC. (US) | 2024-04-30 | — | — | US | disclosed |
| EP-4232042-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-08-30 | — | — | EP | disclosed |
| US-20220177434-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. | 2022-06-09 | — | — | US | disclosed |
| US-20220177434-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS, INC. | 2022-06-09 | — | — | US | disclosed |
| WO-2022087083-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
| WO-2022087083-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220177434-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | MRGPRX2, MRGPRX1, MRGPRX4 | GRM5 184/4885MCHR1 34/4885ADRA2A 173/4885 |
| US-20240351987-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | MRGPRX2, MRGPRX1, MRGPRX4 | GRM5 163/4885MCHR1 37/4885ADRA2A 133/4885 |
| US-11970452-B2 | Modulators of mas-related G-protein receptor X2 and related products and methods | MRGPRX2, MRGPRX1, MRGPRX4 | GRM5 184/4885MCHR1 34/4885ADRA2A 173/4885 |
| US-12384748-B2 | Modulators of mas-related g-protein receptor X2 and related products and methods | MRGPRX2, MRGPRX1, MRGPRX4 | GRM5 163/4885MCHR1 37/4885ADRA2A 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.