MRGPRX2

Mas-related G-protein coupled receptor member X2 · Q96LB1 · MRGPRX2 on Sugi Atlas →

15,108 patent compounds predicted against MRGPRX2, 10,453 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Morphine 3-Glucuronide (SCHEMBL614298)	0.74	6/20
Norcodeine (SCHEMBL120270)	1.00	5/20
Norcodeine (SCHEMBL120271)	1.00	5/20
SCHEMBL46251	0.76	5/20
Codeine (SCHEMBL250022)	0.72	5/20
SCHEMBL918542	0.67	5/20
Morphine (SCHEMBL2997)	1.00	4/20
Codeine (SCHEMBL3257)	1.00	4/20
SCHEMBL154048	1.00	4/20
Morphine (SCHEMBL487690)	1.00	4/20
Morphine (SCHEMBL819981)	1.00	4/20
Codeine (SCHEMBL548093)	0.98	4/20
Codeine (SCHEMBL548094)	0.98	4/20
Morphine (SCHEMBL40902)	0.98	4/20
Morphine (SCHEMBL548141)	0.98	4/20
Codeine (SCHEMBL25901)	0.96	4/20
Codeine (SCHEMBL436793)	0.96	4/20
Morphine (SCHEMBL147362)	0.96	4/20
Morphine (SCHEMBL619013)	0.96	4/20
Codeine (SCHEMBL24578)	0.93	4/20

Clinical trials — most relevant to MRGPRX2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma	PHASE4	COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis	PHASE2	COMPLETED
Effect of OC459 on the Response to Rhinovirus Challenge in Asthma	PHASE2	COMPLETED
Exploration Of Key Targets And Biomarkers Involved In An Allergic Response In Subjects With Allergic Rhinitis (Hay Fever)	PHASE1	COMPLETED
Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications	PHASE1	UNKNOWN
A Phase 1 Study of GTX-B001 in Healthy Subjects and Patients With Chronic Inducible Urticaria	PHASE1	RECRUITING
Study of the Mechanisms of Asthma	PHASE1	COMPLETED
Unraveling the Pathogenesis of Pruritus in Intrahepatic Cholestasis of Pregnancy	nan	UNKNOWN
Investigation of the Pruritogens of Liver-related Diseases	nan	UNKNOWN
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
The Severe Asthma Research Program III-Boston Clinical Site	nan	COMPLETED
Longitudinal Analysis of Amylin Levels in Migraine Patients Undergoing an Anti- CGRP/CGRPr Treatment	nan	NOT_YET_RECRUITING
Histamine Responsiveness in McCune-Albright Syndrome	nan	COMPLETED
B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma	nan	UNKNOWN
Plasma Levels of CGRP and Expression of Specific microRNAs in Blood Cells of Episodic and Chronic Migraine Subjects	nan	COMPLETED
Molecular Mechanism of Asthma	nan	WITHDRAWN
Repeat Immunoadsorption Post Covid ME/CFS	nan	COMPLETED
BIOmarkers of MIGraine: a Proof of Concept Study Based on the Stratification of Responders to CGRP Monoclonal Antibodies	nan	COMPLETED
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
Allergy and Immunology Natural History Study	nan	RECRUITING
Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to Treatments	nan	RECRUITING
Mechanisms of Acute Asthma Exacerbations Through Molecular Analysis of Airway Secretions and Tissues	nan	COMPLETED
Thrombin Regulated Platelet Activation	nan	COMPLETED
Inhibitory Receptors in Eosinophils of Atopic Subjects	nan	COMPLETED
Longitudinal Observational Study of Severe Asthma	nan	COMPLETED
Refractory Asthma Stratification Programme (RASP) Bronchoscopy Study	nan	UNKNOWN
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers	nan	COMPLETED
Identification of an Asthma Susceptibility Gene on 3P	nan	COMPLETED
Development of Therapeutic Approaches Modulating Molecular Targets Implicated on Cancer Stem Cell-related Aggressiveness	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a MRGPRX2 binder may also engage these)

Protein	Name	Similarity
Q4QXU3	—	1.000	Q4QXU3 →
Q4QXU4	—	1.000	Q4QXU4 →
Q4QXX9	—	1.000	Q4QXX9 →
Q4QXU5	—	1.000	Q4QXU5 →
Q4QXU6	—	1.000	Q4QXU6 →
Q5U9D9	—	1.000	Q5U9D9 →
Q4QXU0	—	1.000	Q4QXU0 →
Q4QXU2	—	0.999	Q4QXU2 →
MRGPRX4	Mas-related G-protein coupled receptor member X4	0.995	landscape →
MRGPRX1	Mas-related G-protein coupled receptor member X1	0.995	landscape →
Q96LB0	—	0.993	Q96LB0 →
Q2LL16	—	0.993	Q2LL16 →
Q7TN45	—	0.989	Q7TN45 →
Q91ZC6	—	0.983	Q91ZC6 →
Q7TN49	—	0.982	Q7TN49 →
Q91WW5	—	0.980	Q91WW5 →
Q91WW4	—	0.971	Q91WW4 →
Q3UG61	—	0.971	Q3UG61 →
Q7TN50	—	0.970	Q7TN50 →
Q91ZB9	—	0.970	Q91ZB9 →
Q8CIP3	—	0.970	Q8CIP3 →
Q91WW3	—	0.970	Q91WW3 →
Q91ZC0	—	0.970	Q91ZC0 →
Q91ZC7	—	0.970	Q91ZC7 →
Q8R4G1	—	0.969	Q8R4G1 →
Q91ZC5	—	0.969	Q91ZC5 →
Q3KNA1	—	0.966	Q3KNA1 →
Q3UG50	—	0.966	Q3UG50 →
Q91ZC4	—	0.965	Q91ZC4 →
Q91WW2	—	0.956	Q91WW2 →