Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.63 |
| ▸ | FLT1 | P17948 | 3/20 | 0.63 |
| ▸ | FLT4 | P35916 | 3/20 | 0.63 |
| ▸ | RET | P07949 | 1/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.63 |
| ▸ | KIT | P10721 | 1/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | TEK | Q02763 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435942 | 0.88 | KDR (0.57) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2435186 | 0.86 | KDR (0.63) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2435244 | 0.83 | KDR (0.71) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2748909 | 0.82 | KDR (0.67) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2747307 | 0.81 | KDR (0.75) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL4548727 | 0.81 | KDR (0.78) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2748337 | 0.80 | KDR (0.68) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL4548726 | 0.80 | KDR (0.75) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL4548725 | 0.79 | KDR (0.71) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2436244 | 0.78 | KDR (0.83) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |