Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | RORB | Q92753 | 2/20 | 0.34 |
| ▸ | SCN1A | P35498 | 4/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.32 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.30 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19925061 | 1.00 | MAPK3 (0.38) | MAPK3TSHRRORCRORBSCN1A | |
| SCHEMBL19970023 | 1.00 | MAPK3 (0.38) | MAPK3TSHRRORCRORBSCN1A | |
| SCHEMBL29464368 | 1.00 | MAPK3 (0.38) | MAPK3TSHRRORCRORBSCN1A | |
| SCHEMBL22323177 | 1.00 | MAPK3 (0.38) | MAPK3TSHRRORCRORBSCN1A | |
| SCHEMBL19970018 | 1.00 | MAPK3 (0.38) | MAPK3TSHRRORCRORBSCN1A | |
| SCHEMBL19925074 | 0.95 | CCNT1 (0.34) | MAPK3RORCRORBSCN1ASCN8A | |
| SCHEMBL29464388 | 0.95 | CCNT1 (0.34) | MAPK3RORCRORBSCN1ASCN8A | |
| SCHEMBL19925214 | 0.93 | SCN1A (0.33) | RORCRORBSCN1ASCN8AHSD11B1 | |
| SCHEMBL19925771 | 0.93 | SCN1A (0.33) | RORCRORBSCN1ASCN8AHSD11B1 | |
| SCHEMBL19951375 | 0.91 | SYK (0.38) | TSHRRORCSCN1ASCN8AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220127247-A1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA THE GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION (GNF) | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127247-A1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | CFTR, P2RY1, P2RX5 | MAPK3 3255/4885TSHR 1749/4885RORC 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.