Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.66 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134733 | 1.00 | CHRNB2 (0.66) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL28233502 | 1.00 | CHRNB2 (0.66) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL29688629 | 0.98 | CHRNB2 (0.64) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL10648778 | 0.98 | CHRNB2 (0.64) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL13100347 | 0.94 | CHRNB2 (0.65) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL168915 | 0.94 | CHRNB2 (0.65) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| Pyridine SCHEMBL27552784 | 0.85 | CHRNB2 (0.73) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| Acetic Acid SCHEMBL28811721 | 0.83 | CHRNB2 (0.53) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL20449140 | 0.81 | CHRNB2 (0.62) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 | |
| SCHEMBL20449139 | 0.81 | CHRNB2 (0.62) | CHRNB2CHRNA4MEN1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-07-11 | — | — | US | disclosed |
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | CHRNB2 3217/4885CHRNA4 2950/4885MEN1 142/4885 |
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | CHRNB2 3217/4885CHRNA4 2950/4885MEN1 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.