Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAF1 | P21675 | 16/20 | 0.81 |
| ▸ | BRD9 | Q9H8M2 | 15/20 | 0.81 |
| ▸ | BRD4 | O60885 | 15/20 | 0.81 |
| ▸ | CECR2 | Q9BXF3 | 13/20 | 0.81 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.81 |
| ▸ | BRD2 | P25440 | 1/20 | 0.81 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.81 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.81 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.81 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.81 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.81 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.81 |
| ▸ | BRWD1 | Q9NSI6 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17749704 | 0.90 | BRD9 (1.00) | TAF1BRD9BRD4CECR2TRIM24 | |
| SCHEMBL17749703 | 0.90 | BRD9 (1.00) | TAF1BRD9BRD4CECR2TRIM24 | |
| SCHEMBL17748889 | 0.84 | TAF1 (1.00) | TAF1BRD9BRD4CECR2TRIM24 | |
| SCHEMBL17749807 | 0.80 | TAF1 (1.00) | TAF1BRD9BRD4CECR2TRIM24 | |
| SCHEMBL17749806 | 0.80 | TAF1 (1.00) | TAF1BRD9BRD4CECR2TRIM24 | |
| SCHEMBL17758450 | 0.79 | CECR2 (1.00) | TAF1BRD9BRD4CECR2TAF1L | |
| SCHEMBL17749880 | 0.79 | TAF1 (1.00) | TAF1BRD9BRD4CECR2TRIM24 | |
| SCHEMBL19640301 | 0.79 | TAF1 (1.00) | TAF1BRD9BRD4CECR2TRIM24 | |
| SCHEMBL30073457 | 0.78 | TAF1 (1.00) | TAF1BRD9BRD4CECR2TAF1L | |
| SCHEMBL17758602 | 0.78 | TAF1 (1.00) | TAF1BRD9BRD4CECR2TAF1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218375-B1 | SUBSTITUTED PYRROLOPYRDINES AS INHIBITORS OF BROMODOMAIN | GENENTECH INC (US) | 2022-04-27 | — | — | EP | disclosed |